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1 한약에 관한 연구

1. 결론의 확신 정도 definitely, may 등은 편의(bias)의 개입을 제거한 연구의 질 (quality of evidence, quality of methodology)에 전적으로 의존한다.
2. CAM 논문은 아무리 효과가 좋고, 연구 설계를 최대한으로 끌어 올려도, 보수적인 리뷰어들은 '결과 선언의 확신도가 연구의 질에 비해 높다'는 이유로 최대한 겸손한 표현을 쓸 것을 요구한다.
3. 단순히 결론의 may는 임상에 적용하기 어렵다로 보긴 힘들다.

• IF 10점 이상의 journal은 의학연구 10만 건에 100건 정도 나올까 하는 비율. 연구자가 적고, 연구 수행/방법론/개수 에 제한점이 있으며, 따라서 피인용 비율도 낮을 수 밖에 없는 CAM(보완대체의학) 분야에서 IF 10 이상을 찾는 것은 이상적인 접근이다.

1.1 간독성에 대한 안전성

• Ji Young Lee, Seung Ah Jun, Sung Shin Hong, Yo Chan Ahn, Dong Soo Lee, Chang Gue Son. (2016). Systematic Review of Adverse Effects from Herbal Drugs Reported in Randomized Controlled Trials. Phytotherapy Research. 30(9):1412-9.
  URL: https://pubmed.ncbi.nlm.nih.gov/27196988/

• Yoo Seob Shin , Yong-Won Lee, Young Hwa Choi, Byungjoo Park, Young Koo Jee, Sung-Kyu Choi, ... Chein-Soo Hong. (2009). Spontaneous reporting of adverse drug events by Korean Regional Pharmacovigilance Centers. Pharmacoepidemiol Drug Saf. 18(10):910-5.
  URL: https://pubmed.ncbi.nlm.nih.gov/19621345/

• Hee Kwon, Suk-Hyang Lee, Seong-Eun Kim, Jae-Hyun Lee, Yung-Koo Jee, Hye-Ryun Kang. (2012). Spontaneously reported hepatic adverse drug events in Korea: Multicenter Study. 27(3):268-73.
  URL: https://pubmed.ncbi.nlm.nih.gov/22379337/

• Woo HJ, Kim HY, Choi ES, Cho YH, Kim Y, Lee JH, Jang E. Drug-induced liver injury: A 2-year retrospective study of 1169 hospitalized patients in a single medical center. Phytomedicine. 2015 Dec 1;22(13):1201-5.
  URL: https://pubmed.ncbi.nlm.nih.gov/22379337/

• Jeong TY, Park BK, Cho JH, Kim YI, Ahn YC, Son CG. A prospective study on the safety of herbal medicines, used alone or with conventional medicines. J Ethnopharmacol. 2012 Oct 11;143(3):884-8.
  URL: https://www.sciencedirect.com/science/article/abs/pii/S0378874

• Woo-Jin Lee et al. Systematic review on herb-induced liver injury in Korea. Food Chem Toxicol. 2015 Oct;84:47-54.
  URL: https://pubmed.ncbi.nlm.nih.gov/30639232/

• Jinho Lee et al. Liver enzyme abnormalities in taking traditional herbal medicine in Korea: A retrospective large sample cohort study of musculoskeletal disorder patients. journal of ethnopharmacology. 2015 Jul 1;169:407-12.
  URL: https://pubmed.ncbi.nlm.nih.gov/25956676/

자생한방병원에서 한약을 복용한 근골격계질환 입원환자 32675명의 입원환자 중에서, 입원 혹은 퇴원시 간기능검사에서 간손상을 나타낸 6984명의 환자들을 추적조사한 후향적 연구로, journal of ethnopharmacology(IF 3.055)에 게재되었다.

이에 대해 대한간학회가 반박하였으며, 자생한방병원이 재반박하였다. 또한 2019년 자생한방병원에서 보완논문을 출판하였다.

• Cho JH et al. A nationwide study of the incidence rate of herb-induced liver injury in Korea. Arch Toxicol. 2017;91(12):4009-15.
  URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719126/ (IF,5)

• Jinho Lee et al. Battle Over Herb-Induced Liver Injury: Low Prevalence Confirmed through Secondary Evaluation and Research Team's Clarifying Rebuttal to Unwarranted Public Claims. J Altern Complement Med. 2019;25(3):260–264.
  URL: https://pubmed.ncbi.nlm.nih.gov/30407070/

2015년 자생한방병원의 대규모 관찰연구에 대한 많은 비판이 쏟아지자, 자생한방병원에서는 2019년에 이를 보강한 재반론 논문을 출판하였다(J Altern Complement Med IF 2.256).

• Jung-Hwan Byeon et al. Systematic review of published data on herb induced liver injury. J Ethnopharmacol. 2019 Apr 6;233:190-196.
  URL: https://pubmed.ncbi.nlm.nih.gov/30639232/

1.2 간질환에 대한 유효성

• Dong, H., Lu, F. & Zhao, L. Chinese herbal medicine in the treatment of nonalcoholic fatty liver disease. Chinese Journal of Integrative Medicine. Med. 18, 152–160 (2012).
  URL: https://doi.org/10.1007/s11655-012-0993-2

• Jong-Chol Cyong, Sun-Min Kim, Koji Iijima, Takao Kobayashi and Minoru Furuya. Clinical and Pharmacological Studies on Liver Disease Treated with Kampo Herbal Medicine. The American Journal of Chinese Medicine. Vol. 28, No. 03n04, pp. 351-360 (2000)
  URL: https://doi.org/10.1142/S0192415X00000416

• Der-Shiang Tsai, Mei-Hsuen Huang, Yuan-Shiun Chang, Tsai-Chung Li & Wen-Huang Peng. The use of Chinese herbal medicines associated with reduced mortality in chronic hepatitis B patients receiving lamivudine treatment. J Ethnopharmacol. 2015 Nov 4;174:161-7.
  URL: https://www.ncbi.nlm.nih.gov/pubmed/26277491

(한약, 만성 b형 간염, 2015년, if=3.4)

• Bushenjianpi formula combined with entecavir for HBeAg-negative chronic hepatitis B patients: a multicentre, randomised, double-blind, placebo-controlled trial https://doi.org/10.1016/S0140-6736(16)31960-2

(한약, 만성 b형간염, The Lancet, IF 60.392) 보신건비처방(한약)과 바라크루드(양약) 병용요법

1.3 기타 질환

Kampo medicines for gastrointestinal tract disorders: a review of basic science and clinical evidence and their future application
https://www.ncbi.nlm.nih.gov/pubmed/23503839
(한약, 위장질환, 2013년, IF 4.0)

Efficacy and safety of traditional chinese medicine (Shenqi particle) for patients with idiopathic membranous nephropathy: a multicenter randomized controlled clinical trial.
(한약, 2013년, 신증후군, if=7.62)

Efficacy and Safety of Yokukansan in Treatment-Resistant Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial (A Positive and Negative Syndrome Scale, Five-Factor Analysis
(한약, 2015년, 조현병, if=3.424)

A systems approach to traditional oriental medicine https://www.nature.com/articles/nbt.3167
(한의학 처방 원리(군신좌사), 2015년, 신약개발 KAIST 이상엽 특훈교수팀 IF 39.08 (해당분야 상위 0.6% 수준))
https://m.ibric.org/trend/news/subread.php?Board=news&id=257328 (2019년 해당 논문사 IF 36.558)

A Two-Year Treatment of Amnestic Mild Cognitive Impairment using a Compound Chinese Medicine: A Placebo Controlled Randomized Trail.
(한약, 2016년, 경도인지장애, if=4.122)

Efficacy of Chinese herbal medicine compared with metformin for glucose regulation and cardiovascular risk factors in patients with type 2 diabetes with dyslipidaemia: a multicentre, randomised clinical trial
https://www.thelancet.com/journals/landia/article/PIIS2213-8587(16)30385-0/fulltext
결론 : JTTZF(Jiangtangtiaozhi decoction) showed improvements in several cardiovascular risk factors compared with metformin
JTTZF might be a promising alternative treatment for patients with type 2 diabetes.
(한약, 2016년, 2형당뇨병, The lancet diabetes & endocrinology, IF 25.34)

Traditional Chinese medicine may benefit some heart disease patients
https://www.eurekalert.org/pub_releases/2017-06/acoc-tc060817.php
(한약, 심혈관질환, 2017년, if=17)

Evaluation of cardiovascular risk associated with SKI306X use in patients with osteoarthritis and rheumatoid arthritis https://pubmed.ncbi.nlm.nih.gov/28602866/
(한약, 조인스정(위령선+괄루근+하고초), 류마티스 관절염과 심혈관 질환, 2017년, Journal of Ethnopharmacology IF 3.690)

Suanzaoren formulae for insomnia: updated clinical evidence and possible mechanisms.
(한약, 불면증, 2018년 IF 4.40 )

Peucedanum japonicum extract attenuates allergic airway inflammation by inhibiting Th2 cell activation and production of pro－inflammatory mediators
(한약, 식방풍의 항천식 효과(약리), 2018년 Journal of Ethnopharmacology SCI IF＝3.414)

Chinese herbal medicine formula for acute asthma: A multi-center, randomized, double-blind, proof-of-concept trial.
(한약, 2018년, 천식, if=3.237)

The effect of goreisan on the prevention of chronic subdural hematoma recurrence - multicenter, randomized controlled study
(한약, 2018년, 만성경막하혈종, if=5.002)

Effect of wu chu yu tang on gastroesophageal reflux disease: Randomized, double-blind, placebo-controlled trial.
(한약, 위식도역류질환, 2018년, if=4.180)

Rikkunshito simultaneously improves dyspepsia correlated with anxiety in patients with functional dyspepsia: A randomized clinical trial (The DREAM Study)
(한약, 2018년, 소화장애, if=3.803)

Effects of YuPingFeng granules on acute exacerbations of COPD: a randomized, placebo-controlled study.
(한약, 2018년, copd, if=3.274)

Traditional Herbal Medicine Prevents Postoperative Recurrence of Small Hepatocellular Carcinoma: A Randomized Controlled Study
(한약, 2018년, 암, if=6.102)

https://www.ncbi.nlm.nih.gov/pubmed/31379563#
(한약, 보기약과 보혈약의 약리적 경향성, 2019년, IF 3.8)

Codonopsis lanceolata attenuates allergic lung inflammation by inhibiting Th2 cell activation and augmenting mitochondrial ROS dismutase (SOD2) expression https://www.nature.com/articles/s41598-019-38782-6
(한약, 더덕의 기관지염 완화, 2019년, SCIE IF 4.122)
http://www.akomnews.com/bbs/board.php?bo_table=news&wr_id=10724

Evidence and Potential Mechanisms of Traditional Chinese Medicine for the Treatment of Type 2 Diabetes: A Systematic Review and Meta-Analysis
(한약, 당뇨, 2019년, if = 6.133)

Effects and Mechanisms of Traditional Chinese Herbal Medicine in the Treatment of Ischemic Cardiomyopathy.
(한약, 허혈성 심장질환, 2019년, if=5.574)

Efficacy and safety of Chinese herbal medicine for depression: A systematic review and meta-analysis of randomized controlled trials
(한약, 2019년, 우울증, if=4.465)

https://pubmed.ncbi.nlm.nih.gov/31614534/
(한약(작약), 2019년, 혈소판 응집 방지, if=4.85)

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential’ SCIE급 국제학술지 ‘Antioxidants’
출처 : http://www.akomnews.com/bbs/board.php?bo_table=news&wr_id=42473
(한약, 불임, 2020년) , (JCR Q1, 영향력 지수 5.014)

https://www.ncbi.nlm.nih.gov/pubmed/32220922#
(한약, 대사질환, 2020년if=3.3)

http://www.wiznews.co.kr/news/articleView.html?idxno=10187
(한약, 알츠하이머, 2020년, IF5.7)

http://www.cctoday.co.kr/news/articleView.html?idxno=2066534
(한약, 간경화, 2020년, if=3.7)

Meta-Analysis of Paclitaxel-Based Chemotherapy Combined With Traditional Chinese Medicines for Gastric Cancer Treatment
(한약, 2020년, 위암, if=3.845)

Ameliorative effects of Osteo-F, a newly developed herbal formula, on osteoporosis via activation of bone formation
(한약, 2020년, 골다공증, Journal of Ethnopharmacology IF 3.690)
https://pubmed.ncbi.nlm.nih.gov/33212177/

Ameliorative effects of Osteo-F, a newly developed herbal formula, on osteoporosis via activation of bone formation
(한약, 2021년, 골다공증, Journal of Ethnopharmacology IF 3.690)
https://pubmed.ncbi.nlm.nih.gov/33212177/
"골다공증의 한의치료 효능 규명한 논문 SCI 저널 게재"
http://www.akomnews.com/bbs/board.php?bo_table=news&wr_id=42995

2 침에 관한 연구

Acupuncture for Chronic Low Back Pain
(침, 2010년, 요통, NEJM, if 74.699)
https://www.nejm.org/doi/full/10.1056/nejmct0806114

Randomized controlled trial of patching vs acupuncture for anisometropic amblyopia in children aged 7 to 12 years.
(침, 2010년, 소아 부동시성 약시, if=6.617)

http://www.khmcacu.com/?r=home&c=intro/8&p=2&uid=148
(침, 알레르기성 비염, 2013년, IF6)

https://pubmed.ncbi.nlm.nih.gov/27351677/
(침, 발작적 편두통 예방, 2016년, IF 7.890)

A randomised study comparing the effectiveness of acupuncture or morphine versus the combination for the relief of dyspnoea in patients with advanced non-small cell lung cancer and mesothelioma
https://www.ejcancer.com/article/S0959-8049(16)32040-8/abstract https://blog.naver.com/health208/221825347625
(침, 폐암환자의 호흡곤란, 2016년, EJC impact factor 7.275) 영국 로얄 마르스덴 병원 호흡기내과 연구팀

https://academic.oup.com/brain/article/140/4/914/3058778
(침, 손목터널증후군, 하버드의대-한의학연구원 공동연구, 2017년, IF 10.1)
미 하버드 의대도 인정한 '침 치료' 효과
https://science.ytn.co.kr/program/program_view.php?s_mcd=0082&s_hcd=&key=201703101054053389

Effect of Electroacupuncture on Urinary Leakage Among Women With Stress Urinary Incontinence: A Randomized Clinical Trial
https://www.ncbi.nlm.nih.gov/pubmed/?term=28655016
(침, 2017년, 요실금, JAMA, IF 51)

Effect of acupuncture and intervention types on weight loss: a systematic review and meta‐analysis
(침, 메타분석 비만치료, 2018년, IF 7.31)

Vickers AJ, Vertosick EA, Lewith G, MacPherson H, Foster NE, Sherman KJ, et al. Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis. The Journal of Pain. 2018;19(5):455-74
(침, 만성통증, 2018년, IF 5.4)

Effect of Acupuncture vs Sham Acupuncture or Waitlist Control on Joint Pain Related to Aromatase Inhibitors Among Women With Early-Stage Breast Cancer A Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2687355?resultClick=1
(침, 유방암환자, 2018년, JAMA, IF51)

Acupuncture as Adjunctive Therapy for Chronic Stable Angina A Randomized Clinical Trial
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2739058?resultClick=1
(침, 만성협심증, 2019년, JAMA Internal Medicine, IF 18.652)

Reduced tactile acuity in chronic low back pain is linked with structural neuroplasticity in primary somatosensory cortex and is modulated by acupuncture therapy https://www.sciencedirect.com/science/article/pii/S1053811920303852
(침, 만성요통. 2020년 IF 5.902 하버드의대-한국한의학연구원 김형준 박사)
"만성 요통 환자에 침 치료했더니 뇌 구조 변화" https://www.yna.co.kr/view/AKR20200820081200063?input=1195m

Effect of Acupuncture vs Sham Procedure on Chemotherapy-Induced Peripheral Neuropathy Symptoms A Randomized Clinical Trial
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2762629?resultClick=1
(침, 신경성 통증, 2020년, JAMA, IF51)

Effect of True and Sham Acupuncture on Radiation-Induced Xerostomia Among Patients With Head and Neck Cancer A Randomized Clinical Trial https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2757250?resultClick=1
침놓아 암 치료 부작용 줄인다 (미국 텍사스대학교 엠디 앤더슨 암센터 연구팀)
http://kormedi.com/1308582/%ec%b9%a8%eb%86%93%ec%95%84-%ec%95%94-%ec%b9%98%eb%a3%8c-%eb%b6%80%ec%9e%91%ec%9a%a9-%ec%a4%84%ec%9d%b8%eb%8b%a4%ec%97%b0%ea%b5%ac/
(침, 두경부암 환자의 방사선성 구강건조증, 2020년, JAMA, IF51)

Clinical Evidence for Association of Acupuncture and Acupressure With Improved Cancer Pain A Systematic Review and Meta-Analysis https://jamanetwork.com/journals/jamaoncology/fullarticle/2757396
(침, 암성 통증. 2020년, JAMA Oncology, IF 24.799)

Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial https://www.bmj.com/content/368/bmj.m697
(침, 편두통, 2020년, BMJ IF 27.604)

Efficacy of acupuncture treatment to prevent cerebral vasospasm after subarachnoid hemorrhage： A double－blind， randomized， placebo－controlled trial https://pubmed.ncbi.nlm.nih.gov/32876468/
(침, VS 뇌혈관연축, 2020년, IF 2.256)

Baseline Brain Gray Matter Volume as a Predictor of Acupuncture Outcome in Treating Migraine
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066302/ https://blog.naver.com/beanalogue/221915876599
(침, 편두통, 2020년, IF 2.889)

Efficacy and Safety of Electroacupuncture for Insomnia Disorder: A Multicenter, Randomized, Assessor-Blinded, Controlled Trial https://pubmed.ncbi.nlm.nih.gov/33328773/
(침, 불면증, 2020년, Nature and Science of Sleep IF 4.375)
한의학연 "불면증 전침 치료 효과…150명 임상 시험해 확인"
https://m.blog.naver.com/kiompr/222230152647
YTN, 침에 전기 흘리자 불면증 완화...2달 효과 지속
https://www.ytn.co.kr/_ln/0106_202102200351140836

Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture
https://www.cell.com/neuron/fulltext/S0896-6273(20)30532-8
(침, 사이토카인폭풍(패혈증), 2020년, 미국 하버드 의대 Qiufu Ma 교수, Neuron IF 14.415)
https://neuro.hms.harvard.edu/faculty-staff/qiufu-ma

3 미분류

Effectiveness of Integrative Therapy for Parkinson's Disease Management https://pubmed.ncbi.nlm.nih.gov/30863304/
(양한방 통합 치료, 파킨슨병, 2019년, Frontiers in Aging Neuroscience SCI IF 4.504)

1. A Randomized Trial of Tai Chi for Fibromyalgia https://www.nejm.org/doi/full/10.1056/nejmoa0912611
(태극권, 섬유근육통, 2010년, NEJM IF 74.699)

2. Tai Chi and Postural Stability in Patients with Parkinson's Disease https://pubmed.ncbi.nlm.nih.gov/22316445/
(태극권, 파킨슨병, 2012년, NEJM IF 74.699)

3. Tai Chi exercise for psychological well-being among adults with cardiovascular disease: A systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/32515204/
(태극권, 심혈관질환, 2020년, IF 2.296)
http://kormedi.com/1318409/%ED%83%9C%EA%B7%B9%EA%B6%8C-%EC%8B%AC%EC%9E%A5%EB%B3%91-%ED%99%98%EC%9E%90%EC%97%90%EA%B2%8C-%EC%A2%8B%EC%9D%80-%EC%95%BD%EC%97%B0%EA%B5%AC/

Honeybee venom and melittin suppress growth factor receptoractivation in HER2-enriched and triple-negative breast cancer
https://www.nature.com/articles/s41698-020-00129-0

(봉독, 유방암 세포 사멸, 2020년, 호주 해리퍼킨스의학연구소, IF 9.320)